Home > Public Resource > Colostrum Information > Colostrum F.A.Q > Does the immune factors still work after passing through the stomach?
Does the immune factors still work after passing through the stomach?
As the immune factors which support the immune function are primarily made from proteins, passing through the digestive system generally results in degradation of some of these immune factors.
However, previously published studies on whether the immune factors (primarily immunoglobulin G) are digested or broken down in the stomach affecting efficacy have shown a average of 25% igG recovery following digestion. No studies have reported 100% loss of IgG. What is interesting is that a study by Le Franc-Millot et al. 1995 reported the F (ab) region of antibodies (the region which bind to foreign pathogens) actually retail their biological activity.
Below is a chart showing studies of antibody recovery after oral administration of colostrum or serum.
However, previously published studies on whether the immune factors (primarily immunoglobulin G) are digested or broken down in the stomach affecting efficacy have shown a average of 25% igG recovery following digestion. No studies have reported 100% loss of IgG. What is interesting is that a study by Le Franc-Millot et al. 1995 reported the F (ab) region of antibodies (the region which bind to foreign pathogens) actually retail their biological activity.
Below is a chart showing studies of antibody recovery after oral administration of colostrum or serum.
|
Donor |
Recipient |
Preparation |
Source |
Percent % * |
Reference |
Year |
| Bovine | Adult | Powder | IgG, colostrum | 10-20% | McClead et al. | 1988 |
| Bovine | Adult | Powder | IgG, colostrum | ++ | Lissner et al. | 1998 |
| Bovine | Adult | Powder | IgG, colostrum | 49% | Warny et al. | 1999 |
| Bovine | Adult | Powder | IgG, colostrum | 25% | Kelly et al. | 1997 |
| Bovine | Adult | Powder | IgG, serum | ++ | Hanning and Drew | 1994 |
| Bovine | Adult | Powder | IgG, colostrum | 21% | Roos et al. | 1995 |
| Bovine | In vitro | Powder | IgG, colostrum | 20-42% | Petschow and Talbott | 1994 |
| Bovine | In vitro | Powder | IgG, colostrum | 50% | McClead and Gregory | 1984 |
| Bovine | In vitro | Powder | IgG, colostrum | 25% | Kelly et al. | 1997 |
| Bovine | Infant | Powder | IgG, colostrum | 13% | Zinkernagel et al. | 1975 |
| Human | Infant | Liquid | IgG, serum | ~25% | Losonsky et al. | 1985 |
| Human | Infant | Liquid | IgG, serum | 4-12% | Blum et al. | 1981 |
| Human | Rat | Liquid | IgG, serum | 25.70% | Gmoshinkski et al. | 1998 |
| * Represents % of original dose recovered in stool or in vitro sample | ||||||
Our Partners
|
Contact Us
|
