Colostrum Research

  1. THE BOOK: BOVINE COLOSTRUM BASED FUNCTIONAL FOOD: Since colostrum is so beneficial and valuable, there are a lot of research data emerged worldwide. In China, the book Bovine Colostrum based Functional food is typical, this book is written by Dr. Cao, Jinsong with the support of Biolife New Zealand LTD.
  2. Abe H., Saito H, Miyakawa H, et al. (1991) Heat stability of bovine lactoferrin at acidic pH. Journal of Dairy Science. 74:65-71.
  3. Amaducci L, (1988) Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacology Bulletin. 24(1):130-4.
  4. Bellamy W, Takase M, Yamauchi K, Wakabayashi H, Kawase K, Tomita, M. (1992) Identification of the bactericidal domain of lactoferrin. Biochemica Biophys Acta 1121:130-136.
  5. Bhora F, Dunkin, B, Batzri S, et al. (1995) Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgery Res. 59:236-244.
  6. Bitzan MM, Gold BD, Philpott DJ, et al. (1998) Inhibition of Helicobacter pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. The Journal of Infectious Diseases 177:955-961.
  7. Bogstedt AK, Johansen K, Hatta H, et al. (1996) Passive immunity against diarrhoea. Acta Paediatr. 85:125-128.
  8. Buescher E, McIlheran S. (1988) Antioxidant properties of human colostrum. Pediatric Research. 24(1):14-9.
  9. Cao Jin-song, Duan Hai-xia, Functional trial of bovine colostrum and its components administrated orally, China Dairy Industry, 32(8):27-31, 2004 
  10. Cao JinsongWang MinInhibitory Effect of Immunoglobulin G from Bovine Colostrum on the Mixture Fermentation of Streptococcus thermothilus and Lactobacillus bulgaricusChina Dairy Industry, 2002, 30(6):7-10
  11. Casswall T, Sarker S, Albert M, et al. (1998) Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Ailment Pharmacol Therapies 12:563-568.
  12. Cenacchi T, Baggio C, and Palin E. (1987) Human tolerability of oral phosphatidylserine assessed through laboratory examinations. Clinical Trials Journal. 24.
  13. Cochran C, et al. (1998) Cetyl Myristoleate- A Unique Natural Compound Valuable in Arthritis Conditions. Townsend Letter for Doctors and Patients.
  14. Deitch E. (1990) The Role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Archives of Surgery.
  15. Ebina T, Umezu K, Ohyama S, et al. (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet. 2(8357):1029-30.
  16. Francis G, Upton F, Ballard J, McNeil K, Wallace J. (1988) Insulin-like growth factors 1 and 2 in bovine colostrum. Journal of Biochemistry. 251:95-103.
  17. Harmsen MC, Swart PJ, de Bethune MP, et al. (1995) Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. Journal of Infectious Diseases. 172:380-388.
  18. Hasegawa K, Motsuchi W, Tanaka S, Dosako S. (1994) Inhibition with lactoferrin of in vitro infection with human herpes virus. Jpn. Journal of Sci. Biol. 47:73-85.
  19. Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. Journal of Infectious Diseases 156:158-166.
  20. Hirmo S, et al. (1998) Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Analytical Biochemistry 257:63-6.
  21. Huppertz H, Rutkowski S, Busch D, Eisebit R, Lissner R, Karch H. (1999) Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E. coli, and E-coli expressing intimin and hemolysin. Journal of Pediatric Gastroenterology and Nutrition. 29:452-456.
  22. Ikeda M, Sugiyama K, Tanaka T, et al. (1998) Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochemical and biophysical research communications 245:549-553.
  23. Jiang Tie-min, Jia Shi-qian, Chen Li-jun, et al, High-level expression of human lactoferrin in Pichia.Pastoris, China Dairy Industry, 33(5):4-7, 2005
  24. Juskevich J. (1990) Bovine Growth Hormone: Human Food Safety Evaluation. Science. 249:875-883.
  25. Li Y, Tan A, Vlassara T, Vlassara H. (1995) Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation-modified proteins to a conserved motif. Nature Medicine. 1(10):1057-61.
  26. Li-Chan E, Kummer A, Losso J, Kitts D, Nakai S. (1995) Stability of bovine immunoglobulins to thermal treatment and processing. Food Research International. 28: 9-16.
  27. Lissner R, Thurmann P, Merz G, Karch, H. (1998) H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows to healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 36:239-245.
  28. Liu Wei, Luo Yong-kang, Shen Xiao-qin, et al, Study on thermal stability and thermodynamics of IgG from bovine colostrum powder, China Dairy Industry, 33(3):6-9, 2005 
  29. Masaaki I. and et al. (1999) Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clinical and Experimental Metastasis. 17:35-40.
  30. Melchart D, et al. (1998) Echinacea root extracts for the prevention of upper respiratory tract infections: a double-blind placebo controlled randomized trial. Archives of Family Medicine. 7:541-5.
  31. Mero A, et al. (1997) Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology. 83: 1144-1151.
  32. Michalek SM, McGhee JR, Babb JL. (1978) Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infection and Immunity. 19:217-224.
  33. Michalek SM, McGhee JR. (1977) Effective immunity to dental caries: passive transfer to rats to antibodies to Streptococcus mutans elicits protection. Infection and Immunity 17:644-650.
  34. Nitsch A, and Nitsch F. (1998) The clinical use of bovine colostrum. Journal of Orthomolecular Medicine. 13.
  35. Ogra P, Losonsky G, Fishaut M. (1983) Colostrum-derived immunity and maternal-neonatal interaction. New York Academy of Science 409:82-95.
  36. Ouwehand A, Salminen S, Skurnik M, Conway P. (1997) Inhibition of pathogen adhesion by B-lactoglobulin. International Dairy Journal. 7:685-692.
  37. Pakkanen R, Aalto J. (1997) Review paper: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 7:285-297.
  38. Palmer EL, Gary Jr. GW, Black R, Martin ML. (1980) Antiviral activity of colostrum and serum immunoglobulins a and g. Journal of Medical Virology. 5:123-129.
  39. Petschow B, Talbott R. (1994) Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastic acid and digestive enzymes. Journal of Pediatric Gastroenterology and Nutrition. 19:228-235.
  40. Playford RJ, Floyd DN, Macdonald CE, et al. (1999) Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 44:653-658.
  41. Quigley JD, Martin KR, Dowlen HH, Wallis LB, Lamar K. (1994) Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. Journal of Dairy Science. 77:264-269.
  42. Rump JA, Arndt R, Arnold A, et al. (1992)Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clinical Investigator. 70:588-594.
  43. Saito H, Miyakawa H, Tamura Y, Shimamura S, Tomita M. (1991) Potent bactericidal activity of bovine lactoferrin hydrolysate produced by heat treatment at acidic pH. Journal of Dairy Science. 74:3724-3730.
  44. Tacket CO, Binion SB, Bostwick E, Losonsky G, Roy MJ, Edelman R. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg. 47:276-283, 1992.
  45. Ushijima H, Dairaku M, Honnma H, Mukoyama A, Kitamura T. (1990) Immunoglobulin components and anti-viral activities in bovine colostrum. 64:274-279.
  46. Vorland L, Ulvatne H, Andersen J, et al. (1999) Antibacterial effects of lactoferricin B. Scandinavian Journal of Infected Disease 31:179-184.
  47. Watson DL, Francis GL, Ballard FJ. (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. Journal of Dairy Research 59:369-380.
  48. Yamamoto A, Wada O, Suzuki H. (1987) Purification and properties of biologically active chromium complex from bovine colostrum. American Institute of Nutrition. 118(1):39-45.
  49. Zheng Hui-naCao Jin-song, Recent research on the physiological functions of orally administrated bovine colostrum, China Dairy Industry, 33(3):29-32, 2005

Our Partners 


Healtheries logo-3
fonterra-1 Synlait-1

Contact Us


twitter   facebook   V QR60px